He was born in 1935 in a small landholding family in Lyallpur. After matriculation he passed his Fellow of Arts (FA) in first division from Government College Lyallpur with Mathematics as an additional subject. Later on he developed a tendency towards religion and in order to understand religious works he learned ArabicPersianUrdu and English. He used to help his father in working his lands and continued reading books in one hand while ploughing the fields.[2] Molvi Ahmed Mallah taught him Sarf (morphology) and Nahw (syntax) then he sought guidance about logic, philosophy, and other fine arts from Maulana Imadad ul Haq. He became an expert in Arabic language and literature, and entered the field of research.[2]
Muḥammad Ishāq Madnī‘s grave, Millat Town.
He continued delivering sermons in his village mosque till 1983. Later on, he started performing his responsibilities in the principal mosque of Faisalabad named Jamia Masjid Muhammadi Karimia. He became popular, many people reformed their beliefs on account of his Friday sermons. He answered people’s question on Fatawa Online. He had a unique fervent style with which he gave opinions on various religious matters. Ishaq was one of very few religious research scholars who apart from being a traditionalist was also exceptionally pragmatic. Proclaiming on various matters of Sharia he not only established his reasoning on the basis of valid traditions but also never failed to convince his audience with logical arguments. Ishaq had great command over sentiments as well as arguments and for this reason he was held in high esteem among both the Shia and Sunni schools of thought and his speeches were heard with rapt attention. Ishaq died on 21 Shawal 1434 Hijri corresponding to 28 August 2013